King's Daughters Medical Center (KDMC), operating under the name UK King's Daughters, is a hospital system based in Ashland, Kentucky which is the city's largest employer at over 4,000 employees, generating more than $200 million in payroll a year. The hospital, which is owned by the University of Kentucky, is a locally managed, not-for-profit 465-bed facility that offers "cardiac, medical, surgical, pediatric, rehabilitative, psychiatric, cancer, neurological, pain care, wound care and home care" services.

Ashland is a home rule-class city in Boyd County, Kentucky, United States. The largest city in Boyd County, Ashland is located upon a southern bank of the Ohio River at the state border with Ohio and near West Virginia. The population was 21,625 at the 2020 census. Ashland is a principal city of the Huntington–Ashland metropolitan area, referred to locally as the "Tri-State area", home to 376,155 residents as of 2020. Ashland serves as an important economic and medical center for northeastern Kentucky.