UMass Chan Medical School is a public medical school in Worcester, Massachusetts. It is part of the University of Massachusetts system. It is home to three schools: the T.H. Chan School of Medicine, the Morningside Graduate School of Biomedical Sciences, and the Tan Chingfen Graduate School of Nursing, as well as a biomedical research enterprise and a range of public-service initiatives throughout the state.

Worcester is the 2nd most populous city in the U.S. state of Massachusetts and the 114th most populous city in the United States. Named after Worcester, England, the city's population was 206,518 at the 2020 census, also making it the second-most populous city in New England after Boston. Worcester is approximately 40 miles (64 km) west of Boston, 50 miles (80 km) east of Springfield and 40 miles (64 km) north-northwest of Providence. Due to its location near the geographic center of Massachusetts, Worcester is known as the "Heart of the Commonwealth"; a heart is the official symbol of the city. Worcester is the historical seat of Worcester County in central Massachusetts.