UPMC Mercy is a main hospital facility of the University of Pittsburgh Medical Center (UPMC) and is located in the Uptown section of the city of Pittsburgh, Pennsylvania, adjacent to Duquesne University, and a few blocks from the PPG Paints Arena and downtown Pittsburgh. It is the first chartered hospital to have been founded in the city of Pittsburgh and it is also the first hospital in the world to have been established by the Sisters of Mercy. It is also the first teaching hospital in the region, accepting residents to teaching positions beginning in 1848, one year after opening its doors.

The University of Pittsburgh Medical Center (UPMC) is an American integrated global nonprofit health enterprise that has 100,000 employees, 40 hospitals with more than 8,000 licensed beds, 800 clinical locations including outpatient sites and doctors' offices, a 3.8 million-member health insurance division, as well as commercial and international ventures. It is closely affiliated with its academic partner, the University of Pittsburgh. It is considered a leading American health care provider, as its flagship facilities have ranked in U.S. News & World Report "Honor Roll" of the approximately 15 to 20 best hospitals in America for over 15 years. As of 2016, its flagship hospital UPMC Presbyterian was ranked 12th nationally among the best hospitals by U.S. News & World Report and ranked in 15 of 16 specialty areas when including UPMC Magee-Womens Hospital. This does not include UPMC Children's Hospital of Pittsburgh which ranked in the top 10 of pediatric centers in a separate US News ranking.