USS Argonaut (V-4/SF-7/SM-1/A-1/APS-1/SS-166) was a submarine of the United States Navy, the first boat to carry the name. Argonaut was laid down as V-4 on 1 May 1925 at Portsmouth Navy Yard. She was launched on 10 November 1927, sponsored by Mrs. Philip Mason Sears, the daughter of Rear Admiral William D. MacDougall, and commissioned on 2 April 1928. Although never officially designated as "SS-166", at some point she displayed this number on her conning tower.

The Portsmouth Naval Shipyard, often called the Portsmouth Navy Yard, is a United States Navy shipyard on Seavey's Island in Kittery, Maine, bordering Portsmouth, New Hampshire. The naval yard lies along the southern boundary of Maine on the Piscataqua River.