USS Chickasaw was an ironclad Milwaukee-class river monitor built for the United States Navy during the American Civil War. The ship participated in the Battle of Mobile Bay in August 1864, during which she was lightly damaged, and the bombardments of Forts Gaines and Morgan as Union troops besieged the fortifications defending the bay. In March–April 1865, Chickasaw again supported Union forces during the Mobile Campaign as they attacked Confederate fortifications defending the city of Mobile, Alabama.

The Milwaukee-class monitors were a class of four riverine ironclad monitors built during the American Civil War. Several supported Union forces along the Mississippi River in mid-1864 before participating in the Battle of Mobile Bay in August. Chickasaw and Winnebago bombarded Confederate coastal fortifications during the battle and during subsequent operations as well as engaging the ironclad Tennessee II. The other two ships arrived at Mobile Bay after the battle and all four supported the land attacks on Mobile in March–April 1865. Milwaukee struck a torpedo during this time and sank. The surviving three ships were sold in 1874; Chickasaw was converted into a ferry and survived until 1944 when she was scuttled. Her wreck was discovered in 2004.