USS Gamble (DD–123/DM-15) was a Wickes-class destroyer in the United States Navy during World War I, later converted to a minelayer in World War II.

Brevet Lieutenant Colonel John Marshall Gamble was an officer in the United States Marine Corps during the early 19th century. He was the first, and remains the only known, U.S. Marine to command a U.S. Navy ship, commanding the prize ships Greenwich and Sir Andrew Hammond during naval actions in the Pacific during the War of 1812.