USS Gregory (DD-82/APD-3) was a Wickes-class destroyer in the United States Navy during World War I and, as APD-3 World War II. She was named for Admiral Francis Gregory USN (1780–1866). She was converted into a high-speed transport during World War II and was sunk by Japanese warships.

USS Little (DD-79/APD-4), a Wickes-class destroyer in the United States Navy during World War I and World War II. She was the first Navy ship named for George Little (1754–1809).