USS Guest (DD-472), a Fletcher-class destroyer, was a ship of the United States Navy named for Commodore John Guest (1822–1879).

The Fletcher class was a class of destroyers built by the United States during World War II. The class was designed in 1939, as a result of dissatisfaction with the earlier destroyer leader types of the Porter and Somers classes. Some went on to serve during the Korean War and into the Vietnam War.