USS Hambleton (DD-455/DMS-20) was a Gleaves-class destroyer of the United States Navy, named for Purser Samuel Hambleton (1777–1851).

The Gleaves-class destroyers were a class of 66 destroyers of the United States Navy built 1938–42, designed by Gibbs & Cox. The first ship of the class was USS Gleaves. They were the destroyer type that was in production for the US Navy when the United States entered World War II.