USS Indianapolis (CL/CA-35) was a Portland-class heavy cruiser of the United States Navy, named for the city of Indianapolis, Indiana. Launched in 1931, it was the flagship for the commander of Scouting Force 1 for eight years, then flagship for Admiral Raymond Spruance from 1943 to 1945 while he commanded the Fifth Fleet in battles across the Central Pacific during World War II.

The Portland class of heavy cruisers was a class of ships designed and constructed by the United States Navy in 1930. The two ships of the class, Portland and Indianapolis, saw extensive service during the Pacific War in World War II.