USS James Madison (SSBN-627), the lead ship of her class of ballistic missile submarine, was the second ship of the United States Navy to be named for Founding Father James Madison (1751–1836), the fourth President of the United States (1809–1817).

The James Madison class of submarine was an evolutionary development from the Lafayette class of fleet ballistic missile submarine. They were identical to the Lafayettes except for being initially designed to carry the Polaris A-3 missile instead of the earlier A-2. This class, together with the George Washington, Ethan Allen, Lafayette, and Benjamin Franklin classes, composed the "41 for Freedom" that was the Navy's primary contribution to the nuclear deterrent force through the late 1980s. This class and the Benjamin Franklin class are combined with the Lafayettes in some references.