At 5:24 a.m. on 21 August 2017, USS John S. McCain, a United States Navy warship, was involved in a collision with the Liberian-flagged tanker Alnic MC off the coast of Singapore and Malaysia, east of the Strait of Malacca. According to a U.S. Navy press release, the breach "resulted in flooding to nearby compartments, including crew berthing, machinery, and communications rooms." Ten US Navy sailors died as a result of the crash, which prompted the Maritime and Port Authority (MPA) of Singapore to start a multi-agency search-and-rescue (SAR) effort as the agency responsible for coordinating SAR operations within Singapore's Maritime Search and Rescue Region (MSRR). The Singapore Transport Safety Investigation Bureau (TSIB) also launched a marine safety investigation following the collision in accordance with the International Maritime Organisation's Casualty Investigation Code in Singapore's capacity as a coastal state, and published its final report on 8 March 2018. The U.S. Navy announced on 24 August 2017 that it had suspended search-and-rescue efforts for survivors in the open sea to focus on the recovery of the remains of the missing sailors still inside the flooded compartments of the ship. By 27 August, U.S. Navy and United States Marine Corps divers had recovered the remains of all ten sailors. On 12 September 2017, the United States' chargé d'affaires Stephanie Syptak-Ramnath expressed thanks for Singapore's support during the SAR operations. The McCain returned to service in June 2020.

USS John S. McCain (DDG-56) is an Arleigh Burke-class destroyer currently in the service of the United States Navy. She is part of the Destroyer Squadron 23 within the Third Fleet, and has her homeport at Naval Station Everett in Everett, Washington.