The third USS Macdonough (DD-351) was a Farragut-class destroyer in the United States Navy during World War II. She was named for Thomas Macdonough.

The Farragut-class destroyers were a class of eight 1,365-ton destroyers in the United States Navy and the first US destroyers of post-World War I design. Their construction, along with the Porter class, was authorized by Congress on 29 April 1916, but funding was delayed considerably. Limited to 1,500 tons standard displacement by the provisions of the London Naval Treaty of 1930, the ships were laid down beginning in 1932 and were completed by 1935. After 12 years since the last of the previous class of American destroyers was commissioned, the Farraguts were commissioned in 1934 and 1935.