USS Northampton (CL/CA-26) was the lead ship in Northampton-class cruiser, in service with the United States Navy. She was commissioned in 1930, originally classified a light cruiser because of her thin armor but later reclassified a heavy cruiser because of her 8-inch guns. During World War II she served in the Pacific and was sunk by Japanese torpedoes during the Battle of Tassafaronga on 30 November 1942. She was named after the city of Northampton, Massachusetts, the home of former President Calvin Coolidge.

The Northampton-class cruisers were a group of six heavy cruisers built for the United States Navy, and commissioned between 1928 and 1931.