USS Patrick Henry (SSBN-599), named after the American Revolutionary War figure and Founding Father Patrick Henry (1736–1799), was a George Washington class nuclear-powered fleet ballistic missile submarine of the United States Navy. She was later converted into an attack submarine and redesignated SSN-599.

The George Washington class was a class of nuclear-powered ballistic missile submarines deployed by the United States Navy. George Washington, along with the later Ethan Allen, Lafayette, James Madison, and Benjamin Franklin classes, comprised the "41 for Freedom" group of submarines that represented the Navy's main contribution to the nuclear deterrent force through the late 1980s.