USS San Juan (SSN-751), a Los Angeles-class submarine, is the third ship of the United States Navy to be named San Juan, though only the second named for San Juan, Puerto Rico. The contract to build her was awarded to the Electric Boat Division of General Dynamics Corporation in Groton, Connecticut on 30 November 1982 and her keel was laid down on 9 August 1985. She was launched on 6 December 1986 sponsored by Mrs. Sherrill Hernandez, wife of VADM Diego E. Hernández, and commissioned on 6 August 1988.

The Los Angeles class of submarines are nuclear-powered fast attack submarines (SSN) in service with the United States Navy. Also known as the 688 class after the hull number of lead vessel USS Los Angeles (SSN-688), 62 were built from 1972 to 1996, the latter 23 to an improved 688i standard. As of 2024, 24 of the Los Angeles class remain in commission—more than any other class in the world—and they account for almost half of the U.S. Navy's 50 fast attack submarines.