USS Skate (SSN-578) was the third submarine of the United States Navy named for the skate, a type of ray, was the lead ship of the Skate class of nuclear submarines. She was the third nuclear submarine commissioned, the first to make a completely submerged trans-Atlantic crossing, the second submarine to reach the North Pole, and the first to surface there.

The Skate-class submarines were the United States Navy's first production run of nuclear-powered submarines. They were an evolution of the Tang class in everything except their propulsion plants, which were based on the operational prototype USS Nautilus. The four Skate class boats re-introduced stern torpedo tubes. Although among the smallest nuclear-powered attack submarines ever built, the Skate class served for many years, with the last being decommissioned in 1989. USS Skate was the first submarine to surface at the North Pole, on 17 March 1959.