USS Tripoli (LPH-10), an Iwo Jima-class amphibious assault ship, was laid down on 15 June 1964 at Pascagoula, Mississippi, by the Ingalls Shipbuilding Corporation; launched on 31 July 1965; sponsored by Jane Cates, the wife of General Clifton B. Cates, former Commandant of the Marine Corps; and commissioned on 6 August 1966 at the Philadelphia Naval Shipyard. Tripoli was the second US Navy ship named for the Battle of Derna in 1805. It was the decisive victory of a mercenary army led by a detachment of US Marines and US Army soldiers against the forces of Tripoli during the First Barbary War and was the first recorded land battle of the United States fought overseas.

The Iwo Jima-class amphibious assault ships of the United States Navy were the first amphibious assault ships designed and built as dedicated helicopter carriers, capable of operating up to 20 helicopters to carry up to 1,800 marines ashore. They were named for battles featuring the United States Marine Corps, starting with the Battle of Iwo Jima. The first ship of the class was commissioned in 1961, and the last was decommissioned in 2002. The hull classification of "LPH" stands for "Landing Platform Helicopter".