USS Waccamaw (AO-109) was a Cimarron-class replenishment oiler in the United States Navy. She was named after Waccamaw River. The original capacity was 146,000 barrels (23,200 m3).

The Cimarron-class oilers were an underway replenishment class of oil tankers which were first built in 1939 as "National Defense Tankers," United States Maritime Commission Type T3-S2-A1, designed "to conform to the approved characteristics for naval auxiliaries in speed, radius and structural strength", anticipating their militarization in the event of war. "Tentative plans had been reached with the Standard Oil Company of New Jersey to build ten high-speed tankers with the government paying the cost of the larger engines needed for increased speed. By the first week in December [1937], Standard Oil had solicited and received bids from a number of yards providing for the construction of a number of 16,300-ton (deadweight) capacity tankers. Bids were requested for two versions: a single-screw design of 13 knots and a twin-screw design of 18 knots. The price difference between the two would be used to establish the government's cost subsidy for greater speed. Plans and specifications for both designs were prepared for Standard Oil by naval architect E. L. Stewart. It seems certain that the design for the 18-knot tanker evolved out of the bureau's (C&R) design for a fleet oiler."