USS Wilkes (DD-441) was a Gleaves-class destroyer commissioned in the United States Navy from 1941 to 1946. After spending several decades in the reserve fleet, the destroyer was scrapped in 1972.

The Gleaves-class destroyers were a class of 66 destroyers of the United States Navy built 1938–42, designed by Gibbs & Cox. The first ship of the class was USS Gleaves. They were the destroyer type that was in production for the US Navy when the United States entered World War II.