USS Woolsey (DD-437), a Gleaves-class destroyer, was the second ship to be named Woolsey in the United States Navy. It is the first to be named for both Commodore Melancthon Brooks Woolsey and his father Commodore Melancthon Taylor Woolsey.

The Gleaves-class destroyers were a class of 66 destroyers of the United States Navy built 1938–42, designed by Gibbs & Cox. The first ship of the class was USS Gleaves. They were the destroyer type that was in production for the US Navy when the United States entered World War II.