The UW–Milwaukee Panther Arena is an indoor arena located in Milwaukee, Wisconsin. The arena, which seats as many as 12,700 people and offers 41,700 square feet (3,874 m2) of floor space, is part of a larger downtown campus, that includes the Milwaukee Theatre and Wisconsin Center.

Milwaukee is the most populous city in the U.S. state of Wisconsin and the county seat of Milwaukee County. With a population of 577,222 at the 2020 census, Milwaukee is the 31st-most populous city in the United States, and the fifth-most populous city in the Midwest. It is the central city of the Milwaukee metropolitan area, the 40th-most populous metro area in the U.S. Milwaukee is categorized as a "Gamma minus" city by the Globalization and World Cities Research Network, with a regional GDP of over $102 billion in 2020.