Ukraine participated in the Eurovision Song Contest 2021 with the song "Shum" written by Kateryna Pavlenko, Taras Shevchenko and Ihor Didenchuk. The song was performed by the band Go_A, which were announced by the Ukrainian broadcaster Public Broadcasting Company of Ukraine (UA:PBC) as the Ukrainian representative for the 2021 contest on 18 March 2020 after they were due to compete in the 2020 contest with "Solovey" before the event's cancellation. The song "Shum" was selected as the Ukrainian entry on 1 February 2021 and announced on 4 February 2021.

Romania participated in the Eurovision Song Contest 2021 in Rotterdam, the Netherlands. Their entry, "Amnesia" by Romanian singer Roxen, was internally selected by a professional jury panel as part of the partnership between broadcaster Televiziunea Română (TVR) and the singer's label Global Records. Roxen was initially due to compete in the 2020 contest with "Alcohol You", however, the event was ultimately cancelled due to the COVID-19 pandemic. Prior to Eurovision 2021, "Amnesia" was promoted by the release of a music video and several live performances. Romania failed to qualify from the contest's first semi-final on 18 May 2021, placing 12th and scoring a total of 85 points. This marked Romania's third non-qualification, consecutive to the previous ones. During Roxen's stage performance directed by Bogdan Păun and Dan Manoliu, the singer was accompanied by five dancers and was portrayed executing an interpretative dance choreography with them.