Ultimate Comics: X-Men was an ongoing monthly comic-book series published by Marvel Comics. It made its debut in September 2011 as part of the second re-launch of "Ultimate Marvel", though was canceled in 2013. Through the "Ultimate Universe Reborn" tagline following the "Death of Spider-Man", and written by Nick Spencer with art by Paco Medina, the series serves as a continuation of earlier titles such as Ultimate X-Men, Ultimate Comics: X, and the Ultimate Comics: Fallout mini-series. This title also exists alongside other relaunched Ultimate Marvel works, including Ultimate Comics: Spider-Man and Ultimate Comics: Ultimates.

Ultimate Marvel, later known as Ultimate Comics, was an imprint of comic books published by Marvel Comics, featuring reimagined and modernized versions of the company's superhero characters from the Ultimate Marvel Universe, later known as the Ultimate Universe. Those characters include Spider-Man, the X-Men, the Ultimates, the Fantastic Four, and others. The imprint was launched in 2000 with the publication of the series Ultimate Spider-Man and Ultimate X-Men in 2001, followed by The Ultimates and Ultimate Fantastic Four in 2002 and 2004 respectively providing new origin stories for the characters. The reality of Ultimate Marvel is designated as Earth-1610 as part of the Marvel Comics Multiverse.