Ultimate Spider-Man: Total Mayhem was a 2010 action video game for the iOS and Android systems. It was developed and published by Gameloft. The game takes place in the Ultimate Marvel Universe (Earth-1610). It is no longer available for purchase in the App Store for iPhone and Google Play Store for Android. The game features a rogues gallery of villains from the Ultimate Universe, and is played as a series of occurring events rather than an overarching plot. The title received generally favorable reviews from critics, with the iOS version holding an 85/100 on Metacritic.

Spider-Man is a superhero appearing in American comic books published by Marvel Comics. He is a modernized, alternate universe counterpart of Spider-Man who is in his youth, a superhero first created by Stan Lee and Steve Ditko in 1962. The Ultimate version of the character originated in Ultimate Marvel, a line of comic books created in 2000 that is set in a parallel universe with a narrative continuity separate and independent from the main continuity of Marvel Comics stories that began in the 1960s.