Uncle Anesthesia is the fifth studio album by the American band Screaming Trees. It was released in 1991 via Epic Records. It includes three of the four tracks from the band's previous Epic release, Something About Today.

Screaming Trees were an American rock band formed in Ellensburg, Washington, in 1984 by vocalist Mark Lanegan, guitarist Gary Lee Conner, bassist Van Conner, and drummer Mark Pickerel. Pickerel was replaced by Barrett Martin in 1991. Screaming Trees became known as one of the pioneers of grunge along with Melvins, Mudhoney, U-Men, Skin Yard, Soundgarden, Green River, and Malfunkshun, among others. Although widely associated with grunge, the band's sound incorporated hard rock and psychedelic elements.