The Under Secretary of Defense for Research and Engineering, abbreviated USD (R&E), is a senior official of the United States Department of Defense. The USD (R&E) is charged with the development and oversight of technology strategy for the DoD. The post has at various times had the titles Assistant Secretary of Defense for Research and Engineering, or Director of Defense Research and Engineering (DDR&E). The latter title has itself historically varied between the rank of under secretary and that of assistant secretary.

The United States secretary of defense (SecDef) is the head of the United States Department of Defense, the executive department of the U.S. Armed Forces, and is a high-ranking member of the federal cabinet. The secretary of defense's position of command and authority over the military is second only to that of the president of the United States, who is the commander-in-chief. This position corresponds to what is generally known as a defense minister in many other countries. The secretary of defense is appointed by the president with the advice and consent of the Senate, and is by custom a member of the Cabinet and by law a member of the National Security Council.