Union County is a county located in the U.S. state of Mississippi. It was formed in 1870 from Tippah and Pontotoc counties, and in 1874 a portion of Lee County was added. As of the 2020 census, the population was 27,777. Its county seat is New Albany. According to most sources, the county received its name by being a union of pieces of several large counties, like other Union counties in other states. However, other sources say that the name was meant to mark the re-union of Mississippi and the other Confederate states after the Civil War.

Interstate 22 (I-22) is a 202.22-mile-long (325.44 km) Interstate Highway in the US states of Mississippi and Alabama, connecting I-269 near Byhalia, Mississippi, to I-65 near Birmingham, Alabama. I-22 is also Corridor X of the Appalachian Development Highway System (ADHS). Designated in 2012, I-22 follows the route of older U.S. Route 78 (US 78) and is concurrent with the route for all but its eastern most 11 miles (18 km). The freeway mainly spans rural areas and passes numerous small towns along its route, including Fulton, Tupelo, New Albany, and Holly Springs in Mississippi and Jasper, Winfield, and Hamilton in Alabama.