The United Keetoowah Band of Cherokee Indians in Oklahoma is a federally recognized tribe of Cherokee Native Americans headquartered in Tahlequah, Oklahoma. According to the UKB website, its members are mostly descendants of "Old Settlers" or "Western Cherokees," those Cherokees who migrated from the Southeast to present-day Arkansas and Oklahoma around 1817. Some reports estimate that Old Settlers began migrating west by 1800, before the forced relocation of Cherokees by the United States in the late 1830s under the Indian Removal Act.

Wilma Pearl Mankiller was a Native American activist, social worker, community developer and the first woman elected to serve as Principal Chief of the Cherokee Nation. Born in Tahlequah, Oklahoma, she lived on her family's allotment in Adair County, Oklahoma, until the age of 11, when her family relocated to San Francisco as part of a federal government program to urbanize Indigenous Americans. After high school, she married a well-to-do Ecuadorian and raised two daughters. Inspired by the social and political movements of the 1960s, Mankiller became involved in the Occupation of Alcatraz and later participated in the land and compensation struggles with the Pit River Tribe. For five years in the early 1970s, she was employed as a social worker, focusing mainly on children's issues.