United Nations Security Council Resolution 425, adopted on 19 March 1978, five days after the Israeli invasion of Lebanon in the context of Palestinian insurgency in South Lebanon and the Lebanese Civil War, called on Israel to withdraw immediately its forces from Lebanon and established the United Nations Interim Force In Lebanon (UNIFIL). It was adopted by 12 votes to none; Czechoslovakia and the Soviet Union abstained, and China did not participate.

The 1978 South Lebanon conflict began after Israel invaded southern Lebanon up to the Litani River in March 1978, in response to the Coastal Road massacre near Tel Aviv by Lebanon-based Palestinian militants. The conflict resulted in the deaths of 1,100–2,000 Lebanese and Palestinians, 20 Israelis, and the internal displacement of 100,000 to 250,000 people in Lebanon. The Israel Defense Forces gained a military victory against the Palestine Liberation Organization as the latter was forced to withdraw from southern Lebanon, preventing it from launching attacks on Israel from across its land border with Lebanon. In response to the outbreak of hostilities, the United Nations Security Council adopted Resolution 425 and Resolution 426 on 19 March 1978, which called on Israel to immediately withdraw its troops from Lebanon and established the United Nations Interim Force in Lebanon (UNIFIL).