Assistant Secretary of State (A/S) is a title used for many executive positions in the United States Department of State, ranking below the under secretaries. A set of six assistant secretaries reporting to the under secretary for political affairs manage diplomatic missions within their designated geographic regions, plus one assistant secretary dealing with international organizations and one equivalent as the coordinator/ambassador at large for counterterrorism. Assistant secretaries usually manage individual bureaus of the Department of State. When the manager of a bureau or another agency holds a title other than assistant secretary, such as "director", it can be said to be of "assistant secretary equivalent rank". Assistant secretaries typically have a set of deputies, referred to as deputy assistant secretaries (DAS).

The Foreign Service Institute (FSI) is the United States federal government's primary training institution for members of the U.S. foreign service community, preparing American diplomats as well as other professionals to advance U.S. foreign policy objectives overseas and in Washington. FSI provides more than 800 courses—including up to 70 foreign languages—to more than 225,000 enrollees a year from the U.S. Department of State and more than 50 other government agencies and the military service branches. FSI is based at the George P. Shultz National Foreign Affairs Training Center in Arlington, Virginia.