The U.S. Department of Agriculture South Building is an office building located at 14th Street and Independence Avenue, Southwest, Washington, D.C.

Independence Avenue is a major east-west street in the southwest and southeast quadrants of the city of Washington, D.C., in the United States, running just south of the United States Capitol. Originally named South B Street, Independence Avenue SW was constructed between 1791 and 1823. Independence Avenue SE was constructed in pieces as residential development occurred east of the United States Capitol and east of the Anacostia River. Independence Avenue SW received its current name after Congress renamed the street in legislation approved on April 13, 1934. Independence Avenue SW originally had its western terminus at 14th Street SW, but was extended west to Ohio Drive SW between 1941 and 1942. The government of the District of Columbia renamed the portion of the road in the southeast quadrant of the city in 1950.