The Deputy Secretary of Health and Human Services is the Chief Operating Officer of the United States Department of Health and Human Services. The deputy secretary oversees all operations within the Department, including overseeing Medicare, Medicaid, public health, medical research, food and drug safety, welfare, child and family services, disease prevention, Indian health, and mental health services. The current Deputy Secretary is Andrea Palm, who was confirmed by the United States Senate on May 11, 2021.

Andrea Joan Palm is an American government health advisor who is the United States Deputy Secretary of Health and Human Services in the Biden administration. Previously, Palm served as secretary-designee of the Wisconsin Department of Health Services from 2019 to 2021 in the administration of Governor Tony Evers, an office she was never sworn into due to Republican opposition in the Wisconsin Senate.