The United States of America (USA), represented by the United States Olympic Committee (USOC), competed at the 2008 Summer Olympics in Beijing, China. U.S. athletes have competed in every Summer Olympic Games in the modern era, except the 1980 Summer Olympics in Moscow, which was boycotted by the American team and 65 other countries in protest of the Soviet invasion of Afghanistan. The USOC sent a total of 588 athletes to Beijing (310 men and 286 women), and competed in all Olympic sports except handball.

The 2008 Summer Olympics, officially the Games of the XXIX Olympiad and also known as Beijing 2008, were an international multisport event held from 8 to 24 August 2008, in Beijing, China. A total of 10,942 athletes from 204 National Olympic Committees (NOCs) competed in 28 sports and 302 events, one event more than those scheduled for the 2004 Summer Olympics. This was the first time China had hosted the Olympic Games, and the third time the Summer Olympic Games had been held in East Asia, following the 1964 Olympics in Tokyo, Japan, and the 1988 Olympics in Seoul, South Korea. These were also the second Summer Olympic Games to be held in a communist state, the first being the 1980 Summer Olympics in the Soviet Union.