The United States competed at the 2012 Summer Paralympics in London, United Kingdom, from August 29 to September 9, 2012.

The medal table of the 2012 Summer Paralympics ranks the participating National Paralympic Committees (NPCs) by the number of gold medals won by their athletes during the competition. The 2012 Paralympics was the fourteenth Games to be held, a quadrennial competition open to athletes with physical and intellectual disabilities. The games were held in London, United Kingdom, from 29 August to 9 September 2012.