The United States competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 September to 18 September 2016. The first places the team qualified were for three athletes in sailing events. They also qualified athletes in archery, goalball, shooting, swimming, and wheelchair basketball.

The 2016 Summer Paralympics, the 15th Summer Paralympic Games, were a major international multi-sport event for athletes with disabilities governed by the International Paralympic Committee, held in Rio de Janeiro, Brazil, from 7 to 18 September 2016. The Games marked the first time a Latin American and South American city hosted the event, the second Southern Hemisphere city and nation, the first one being the 2000 Summer Paralympics in Sydney, and also the first time a Lusophone (Portuguese-speaking) country hosted the event. These Games saw the introduction of two new sports to the Paralympic program: canoeing and the paratriathlon.