The Université de Sherbrooke is a French-language public research university in Sherbrooke, Quebec, Canada, with a second campus in Longueuil, a suburb on the South Shore of Montreal. It is one of two universities in the Estrie region of Quebec, and the only French-language university for the region.

Sherbrooke is a city in southern Quebec, Canada. It is at the confluence of the Saint-François and Magog rivers in the heart of the Estrie administrative region. Sherbrooke is also the name of a territory equivalent to a regional county municipality (TE) and census division (CD) of Quebec, coextensive with the city of Sherbrooke. With 172,950 residents at the Canada 2021 Census, it is the sixth largest city in the province and the 30th largest in Canada. The Sherbrooke Census Metropolitan Area had 227,398 inhabitants, making it the fourth largest metropolitan area in Quebec and 19th in Canada.