The University–Cultural Center MRA is a pair of multiple property submissions to the National Register of Historic Places which were approved on April 29 and May 1, 1986. The structures included are all located in Midtown, near Woodward Avenue and Wayne State University in Detroit, Michigan. The two submissions are designated the University–Cultural Center MRA Phase I, containing five properties, and the University–Cultural Center MRA Phase II, containing three properties.

Midtown Detroit is a commercial and residential district located along the east and west side of Woodward Avenue, north of Downtown Detroit, and south of the New Center area. The area includes several historic districts. In addition, it contains a residential area of some 14,550 people and covers 2.09 sq mi. The community area of neighborhoods is bounded by the Chrysler Freeway (I-75) on the east, the Lodge Freeway (M-10) on the west, the Edsel Ford Freeway (I-94) on the north, and the Fisher Freeway (I-75) on the south.