The State University of New York at Buffalo, commonly called the University at Buffalo (UB) and sometimes called SUNY Buffalo, is a public research university with campuses in Buffalo and Amherst, New York, United States. The university was founded in 1846 as a private medical college and merged with the State University of New York system in 1962. As of 2022, it is one of two flagship institutions of the SUNY system, along with Stony Brook University. As of fall 2020, the university enrolled 32,347 students in 13 schools and colleges, making it the largest public university in the state of New York.

Buffalo is a city in the U.S. state of New York and the seat of Erie County. It lies in Western New York, at the eastern end of Lake Erie, at the head of the Niagara River, on the United States border with Canada. With a population of 278,349 according to the 2020 census, Buffalo is the 2nd largest city in New York state, 1st being New York City, and the 78th largest city in the United States. Buffalo and the city of Niagara Falls together make up the two-county Buffalo–Niagara Falls Metropolitan Statistical Area (MSA), which had an estimated population of 1.2 million in 2020, making it the 49th-largest MSA in the United States.