The University of California, Irvine is a public land-grant research university in Irvine, California, United States. One of the ten campuses of the University of California system, UCI offers 87 undergraduate degrees and 129 graduate and professional degrees, and roughly 30,000 undergraduates and 6,000 graduate students are enrolled at UCI as of Fall 2019. The university is classified among "R1: Doctoral Universities – Very high research activity", and had $523.7 million in research and development expenditures in 2021. UCI became a member of the Association of American Universities in 1996.

Irvine is the largest city and a master-planned city in central Orange County, California, United States, in the Los Angeles metropolitan area. The Irvine Company started developing the area in the 1960s and the city was formally incorporated on December 28, 1971. The 66-square-mile (170 km2) city had a population of 307,670 at the 2020 census; it is the 63rd most populous city in the United States.