The University of Missouri High School (MU High School) is a distance-learning K-12 high school administered by the University of Missouri, a public state university located in Columbia, Missouri and the flagship of the University of Missouri System. The program was founded in 1999 as part of the university's Center for Distance and Independent Study (CDIS). Its mission is to provide learning opportunities in addition to traditional high schools. The school offers more than 150 courses by certified Missouri teachers, from the elementary through high school levels. Each year thousands of students enroll in high school to succeed in their home high schools and other settings.

The University of Missouri is a public land-grant research university in Columbia, Missouri. It is Missouri's largest university and the flagship of the four-campus University of Missouri System. MU was founded in 1839 as the first public university west of the Mississippi River. It has been a member of the Association of American Universities since 1908 and is classified among "R1: Doctoral Universities – Very high research activity".