The University of Naples Federico II is a public research university in Naples, Campania, Italy. Established in 1224 and named after its founder, Frederick II, it is the oldest public, secular, non-sectarian or state-funded university in the world, and one of the world's ten oldest universities in continuous operation.

Naples is the regional capital of Campania and the third-largest city of Italy, after Rome and Milan, with a population of 909,048 within the city's administrative limits as of 2022. Its province-level municipality is the third-most populous metropolitan city in Italy with a population of 3,115,320 residents, and its metropolitan area stretches beyond the boundaries of the city wall for approximately 30 kilometres.