The University of Puerto Rico, Mayagüez Campus (UPRM) or Recinto Universitario de Mayagüez (RUM) in Spanish, is a public land-grant university in Mayagüez, Puerto Rico. UPRM is the second-largest university campus of the University of Puerto Rico system. In addition to its status as a land-grant university, it is also a member of the sea-grant and space-grant research consortia. In 2009, the campus population was composed of 12,108 students, 1,924 regular staff members, and 1,037 members of the education staff. In 2013, the student population remained relatively steady at 11,838, but the instructional faculty dropped to 684. In the second semester of 2019 around 12,166 students were enrolled. By the end of the academic year 2022-2023 there were 10,071 students enrolled. UPRM has been accredited by the Middle States Commission on Higher Education (MSCHE) since 1946.

Mayagüez is a city and the eighth-largest municipality in Puerto Rico. It was founded as Pueblo de Nuestra Señora de la Candelaria de Mayagüez, and is also known as La Sultana del Oeste, Ciudad de las Aguas Puras, or Ciudad del Mangó. On April 6, 1894, the Spanish Crown granted it the formal title of Excelente Ciudad de Mayagüez. Mayagüez is located in the center of the western coast on the island of Puerto Rico. It has a population of 73,077 in the city proper, and it is a principal city of the Mayagüez Metropolitan Statistical Area and the Mayagüez–San Germán–Cabo Rojo Combined Statistical Area.