University of Saskatchewan has over 200 academic programs on its Saskatoon, Saskatchewan campus, and is internationally known for its teaching and research. The on-campus synchrotron Canadian Light Source makes it the only Canadian institution for such nuclear and biotechnology research. Canadian Light Source nuclear research facility provides research and analysis of the internal structures of advanced materials and biological samples. The College of Arts and Science is the largest of the U of S and comprises five separate health science fields in addition to numerous other programs in the Arts, Social Sciences, Humanities, and Natural Sciences. The Department of Computer Science as well as the College of Engineering are ranked highly within their fields. The founding college, the College of Agriculture, is still providing agricultural breakthroughs which are utilized worldwide.

The Saskatchewan Research Council (SRC) is a provincial treasury board crown corporation engaged in research and technology development on behalf of the provincial government and private industry. It focuses on applied research and development projects that generate profit. Some of its funding comes from government grants, but it generates the balance from selling products and services. With nearly 300 employees and $137 million in annual revenues, SRC is the second largest research and technology organization in Canada.