Upper Takutu-Upper Esequibo is a region of Guyana. It borders the region of Potaro-Siparuni to the north, the region of East Berbice-Corentyne to the east and Brazil to the south and west. It contains the town of Lethem, and the villages of Aishalton, Nappi and Surama. It is also the largest region of Guyana.

Potaro-Siparuni is a region of Guyana. It borders the region of Cuyuni-Mazaruni to the north, the regions of Upper Demerara-Berbice and East Berbice-Corentyne to the east, the region of Upper Takutu-Upper Essequibo to the south and Brazil to the west.