Uptown is a commercial district in southwestern Minneapolis in the U.S. state of Minnesota, that is centered at the intersection of Hennepin Avenue and West Lake Street. It has traditionally spanned the corners of four neighborhoods, Lowry Hill East, East Bde Maka Ska, South Uptown and East Isles neighborhoods, which are all within the Calhoun Isles community. Historically, the boundaries of Uptown are Bde Maka Ska to the west, Dupont Avenue to the east, 31st Street to the south, and 28th Street to the north; though these borders often vary. Uptown is a popular destination for retail, nightlife, and cultural events, and the district was famously written about by recording artist Prince.

Hennepin Avenue is a major street in Minneapolis, Minnesota, United States. It runs from Lakewood Cemetery, north through the Uptown District of Southwest Minneapolis, through the Virginia Triangle, the former "Bottleneck" area west of Loring Park. It then goes through the North Loop in the city center, to Northeast Minneapolis and the city's eastern boundary, where it becomes Larpenteur Avenue as it enters Lauderdale in Ramsey County at Highway 280. Hennepin Avenue is a Minneapolis city street south/west of Washington Avenue, and is designated as Hennepin County Road 52 from Washington Avenue to the county line.