Uptown is a business district in Houston, located 6.2 miles (10.0 km) west of Downtown and is centered along Post Oak Boulevard and Westheimer Road. The Uptown District is roughly bounded by Woodway Drive to the north, the I-610 to the east, Richmond Avenue to the south, and Yorktown Street to the west. It covers 1,010 acres (410 ha).

Houston is the most populous city in the U.S. state of Texas and in the Southern United States. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the seat and largest city of Harris County; as well as the principal city of the Greater Houston metropolitan area, which is the fifth-most populous metropolitan statistical area in the United States and the second-most populous in Texas after Dallas–Fort Worth. With a population of 2,302,878 in 2022, Houston is the fourth-most populous city in the United States after New York City, Los Angeles, and Chicago, and the seventh-most populous city in North America. Houston is the southeast anchor of the greater megaregion known as the Texas Triangle.