Uranium mining in Utah, a state of the United States, has a history going back more than 100 years. Uranium mining started as a byproduct of vanadium mining about 1900, became a byproduct of radium mining about 1910, then back to a byproduct of vanadium when the radium price fell in the 1920s. Utah saw a uranium boom in the late 1940s and early 1950s, but uranium mining declined in the 1980s. Since 2001 there has been a revival of interest in uranium mining, as a result of higher uranium prices.

Uranium mining in Colorado, United States, goes back to 1872, when pitchblende ore was taken from gold mines near Central City, Colorado. The Colorado uranium industry has seen booms and busts, but continues to this day. Not counting byproduct uranium from phosphate, Colorado is considered to have the third largest uranium reserves of any US state, behind Wyoming and New Mexico.