Uxbridge is a town in Worcester County, Massachusetts, United States, first colonized in 1662 and incorporated in 1727. It was originally part of the town of Mendon, and named for the Earl of Uxbridge. The town is located 36 mi (58 km) southwest of Boston and 15 mi (24 km) south-southeast of Worcester, at the midpoint of the Blackstone Valley National Historic Park. The historical society notes that Uxbridge is the "Heart of The Blackstone Valley" and is also known as "the Cradle of the Industrial Revolution". Uxbridge was a prominent Textile center in the American Industrial Revolution. Two Quakers served as national leaders in the American anti-slavery movement. Uxbridge "weaves a tapestry of early America".

Worcester County is a county in the U.S. state of Massachusetts. At the 2020 census, the population was 862,111, making it the second-most populous county in Massachusetts. It is also the largest county in Massachusetts by geographic area. The largest city and traditional shire town is Worcester. Worcester County is part of the Worcester, MA–CT metropolitan statistical area and the Boston-Worcester-Providence combined statistical area.