Uxbridge was a seat returning one Member of Parliament (MP) of the House of Commons of the UK Parliament from 1885 to 2010. Its MPs elected were: Conservative Party candidates for 107 years and Labour Party candidates for 18 years. The closing 40 years of the seat's history saw Conservative victory — in 1997 on a very marginal majority in relative terms.

Uxbridge is a suburban town in west London and the administrative headquarters of the London Borough of Hillingdon. Situated 15.4 miles (24.8 km) west-northwest of Charing Cross, it is one of the major metropolitan centres identified in the London Plan. Uxbridge formed part of the parish of Hillingdon in the county of Middlesex, and was a significant local commercial centre from an early time. As part of the suburban growth of London in the 20th century it expanded and increased in population, becoming a municipal borough in 1955, and has formed part of Greater London since 1965.